isna: Iranian scientist finds breast implants may cause rare lymphoma

SHAFAQNA (International Shia News Association) An Iranian researcher Kaywan Shokrollahi along with his colleagues at Britain’s Liverpool University have reviewed cases of several patients to discover the link between breast implant and lymphoma, and found out that the implants may cause a rare type of cancer.

Typically, women have no problem with breast augmentation but in limited cases, some patients develop anaplastic large cell lymphoma, a rare blood cancer.

Thanks to a new study, researchers and medical professionals have a better understanding as to why this occurs. This blood cancer, also referred to as ALCL, is a rare form of non-Hodgkin lymphoma (NHL), which accounts for just 3% of all NHL diagnoses.

Usually, ALCL shows up in the skin, liver, soft tissue, and lymph nodes but in rare instances, it appears in the breast.

The majority of breast ALCL cases have occurred in patients who underwent augmentation surgery, which involves tumors developing 100% of the time in scar tissue around the area of the implant.

Findings of this study were published in the journal Mutation Research.

As part of the study, all available studies involving ALCL, as well as patient case reports were reviewed. From this, the team identified 71 known cases of anaplastic large cell lymphoma throughout the world, all of them linked to breast implants.

Although extremely rare, this blood cancer affects approximately one of every six women in every three million breast augmentation surgeries.

For all of the studies conducted, women with ALCL were split into two groups consisting of those who have cancer cells with an abnormal surface protein known as anaplastic lymphoma kinase (ALK) and those who do not have this abnormality.

In most cases, patients with ALK-positive ALCL responded quite well to treatment, having a survival rate of five years or more. In comparison, ALK-negative patients typically need a much more aggressive approach when it comes to treatment. For these women, only 50% live past the five-year mark.

The majority of patients analyzed with ALCL relating to breast implants were ALK-negative and m responded positively to treatment. The team had access to treatment progress for 49 cases and discovered that just five deaths had been reported.


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