ISNA/ Iranian researcher finds link between neural stem cell overgrowth

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SHAFAQNA (International Shia News Association) – An Iranian researcher at California University Yasamin Qhouchani, along with her colleagues has found the link between overgrowth of neural stem cells and autism.

People with autism spectrum disorder often experience a period of accelerated brain growth after birth. No one knows why, or whether the change is linked to any specific behavioral changes.

The new study by UCLA researchers demonstrates how, in pregnant mice, inflammation, a first line defense of the immune system, can trigger an excessive division of neural stem cells that can cause “overgrowth” in the offspring’s brain.

The paper appears in the online edition of the journal Stem Cell Reports.

“We have now shown that one way maternal inflammation could result in larger brains and, ultimately, autistic behavior, is through the activation of the neural stem cells that reside in the brain of all developing and adult mammals,” said one of the paper’s senior author and a director of the Neural Stem Cell Research Center at UCLA’s Semel Institute for Neuroscience and Human Behavior.

In the study, the researchers mimicked environmental factors that could activate the immune system, such as an infection or an autoimmune disorder, by injecting a pregnant mouse with a very low dose of lipopolysaccharide, a toxin found in E. coli bacteria.

The researchers discovered the toxin caused an excessive production of neural stem cells and enlarged the offspring’s’ brains.

Neural stem cells become the major types of cells in the brain, including the neurons that process and transmit information and the glial cells that support and protect them.

Notably, the researchers found that mice with enlarged brains also displayed behaviors like those associated with autism in humans.

For example, they were less likely to vocalize when they were separated from their mother as pups, were less likely to show interest in interacting with other mice, showed increased levels of anxiety and were more likely to engage in repetitive behaviors like excessive grooming.

The researchers also found evidence that the brain growth triggered by the immune reaction was even greater in mice with a specific genetic mutation, a lack of one copy of a tumor suppressor gene called phosphatase and tensin homolog, or PTEN.

The PTEN protein normally helps prevent cells from growing and dividing too rapidly.

In humans, having an abnormal version of the PTEN gene leads to very large head size or macrocephaly, a condition that also is associated with a high risk for autism.

In addition, the team found that the proliferation of neural stem cell and brain overgrowth was stimulated by the activation of a specific molecular pathway.

(A pathway is a series of actions among molecules within a cell that leads to a certain cell function.)

This pathway involved the enzyme NADPH oxidase, which the UCLA researchers have previously found to be associated with neural stem cell growth.

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